Sphingolipids regulate [Mg2+]o uptake and [Mg2+]i content in vascular smooth muscle cells: potential mechanisms and importance to membrane transport of Mg2+
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Sphingolipids regulate [Mg ]o uptake and [Mg ]i content in vascular smooth muscle cells: potential mechanisms and importance to membrane transport of Mg
Tao Zheng, Wenyan Li, Bella T. Altura, Nilank C. Shah, and Burton M. Altura Departments of Physiology and Pharmacology and Medicine, Center For Cardiovascular and Muscle Research, The School of Graduate Studies Program in Molecular and Cellular Science, State University of New York, Health Science Center at Brooklyn, Box31, 450 Clarkson Avenue, Brooklyn; and Bio-Defense Systems Inc., Rockville ...
متن کاملSphingolipids regulate [ Mg 2 + ] 0 uptake and [ Mg 2 + ] i content in vascular smooth muscle cells : potential mechanisms and importance to membrane transport of Mg 2 +
Zheng T, Li W, Altura BT, Shah NC, Altura BMSphingolipids regulate [Mg2 +]0 uptake and [Mg2 +]; content in vascular smooth muscle cells: potential mechanisms and importance to membrane transport of Mg + . Am J Physiol Heart Circ Physiol 300: H486H492, 2011. First published November 26, 20 I 0; doi: 1 0.1152/ajpheart.00976.20 1 0.-Sphingolipids have a variety of important signaling roles in mamm...
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Increasing experimental evidence has demonstrated that sphingolipids are likely to have an important regulatory function in the cardiovascular system. Two sphingolipids released from activated platelets, and therefore of particular relevance, are S1P (sphingosine 1-phosphate) and SPC (sphingosylphosphocholine). Both S1P and SPC can act as vasoconstrictors and may modulate VSMC (vascular smooth ...
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Depression is associated with vascular disease, such as myocardial infarction and stroke. Pharmacological treatments may contribute to this association. On the other hand, Mg(2+) deficiency is also known to be a risk factor for the same category of diseases. In the present study, we examined the effect of imipramine on Mg(2+) homeostasis in vascular smooth muscle, especially via melastatin-type...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2011
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00976.2010